Major aspects of mesenchymal stem cell signaling and differentiation into osteoblasts in the optimization of bone formation for dental implant: a systematic review

Introduction: In recent decades, the number of dental implant procedures has shown significant growth worldwide, reaching about one million implants per year. Brazil, in there been a very rapid evolution dentistry with high success rates. Several materials can be used as bone graft, each different properties, for example, regarding neovascularization. Guided regeneration favors formation new tissue. When grafting are required, focus is often on type biomaterial to and predictability results. Objective: It was carry out concise systematic review processes using biomaterials main molecular cellular constituents dentistry. Methods: The survey carried from January February 2023 Scopus, PubMed, Science Direct, Scielo databases, older scientific articles gold standard reference up 2022. quality studies based GRADE instrument risk bias by Cochrane instrument. Results Conclusion: founded 128 that underwent eligibility analysis. final sample had 34 eligible were described review. Most showed homogeneity their results, X2=89.8.8% <50%. Due biological barriers graft surgeries, technological these they point potential tools treating loss. greater guided associated material due higher grade vital lower percentage residual particles. All studied substitute resulted efficient alveolar ridge preservation procedures.